Clinic Letter

*Final Report*
Age: Patient is an 18-month boy.
CHIEF COMPLAINT: Perisylvian syndrome/polymicrogyria

HISTORY OF PRESENT ILLNESS: Parents report that "D" has had no recent seizures or spasms. His last seizure occurred over a year ago. He will occasionally startle with loud noises. Parents report that he will extend his neck and flex his arms forward when this occurs. It appears that D has lost 1 pound since his last visit. The dietitian was consulted and met with the parents to discuss methods for increasing D's caloric intake.

CURRENT DEVELOPMENT: D is in EI program where he receives PT and OT. He also receives PT/OT and speech at Beaumont Hospital twice a week each. D has been making small gains in his development. He has started using his upper extremities more frequently. He is reaching out for objects. He is able to roll from side to side. He is using a gait trainer, taking a few steps in physical therapy. He is babbling a few consonants, but has no speech yet.

PHYSICAL EXAMINATION: D weighs 23 lbs; heart rate is 101 and blood pressure 103/66. D is well-nourished, well-developed, in no acute distress. He is alert, interactive and making good eye contact. Of note, he is drooling quite a bit. Lungs are clear to auscultation bilaterally. Heart has a regular rate and rhythm. Abdomen is soft and not tender. On musculoskeletal exam, strength is 4/5 in upper and lower extremities. D has good head and neck control, but very poor trunk control. He has increased tone in his bilateral upper extremities, bilateral lower extremities. NO parachute reflex was noted.

NEUROLOGICAL EXAMINATION: D is alert, interactive. Pupils are equal, round and reactive. Extraocular movements are intact. There is a positive red reflex. Fundi are not well visualized. NO facial asymmetry. Palate elevates with phonation. Deep tendon reflexes are +2 throughout.

PREVIOUS DIAGNOSTIC STUDIES: D has a VMR in November 2006 which was abnormal with a slow background, occasional spike and wave activity was seen in the right temporo-parieto-occipial region. There were ten events by the parents that were not associated with epileptic activity. D had a CT scan in August 2006 which showed PMG along the perisylvian areas of the brain with a moderate degree of ventriculomegaly. There was no evidence of craniosynostosis on this exam. D also has a barium swallow recently which showed no aspiration, but did show some oral motor dysfunction

IMPRESSION: Perisylvian syndrome, polymicrogyria and epilepsy

TREATMENT PLAN: Continue vigabatrin 250 mg in the morning and 500 mg at bedtime. D will be scheduled for a PET scan. Parents are to call with any questions or concerns. D should return to clinic in four months.